General Health Scientific References
Fertility | Women's Health | Urology | Rheumatology | General Health
LATEST RESEARCH UPDATE: A recent meta-analysis published in the Journal of the American Heart Association found that coenzyme Q10 (CoQ10) supplementation ameliorated statin associated muscle symptoms (SAMs) such as muscle pain, muscle weakness, muscle cramps, and muscle tiredness. This meta-analysis included 12 randomized controlled trials of intervention ranging from 1-3 months, with a total of 575 participants. Compared to placebo, CoQ10 ameliorated muscle pain, muscle weakness, muscle cramps, and muscle tiredness. The authors concluded that CoQ10 supplementation may be a complementary approach to statin-induced myopathy. For more information check out the full study.
Bone Health
(2008/04) Is boron nutritionally relevant?
(2003/06) The physiological effects of dietary boron.
(1995/02) Effect of boron supplementation on blood and urinary calcium, magnesium, and phosphorus, and urinary boron in athletic and sedentary women.
(1994/11) Essentiality of Boron for Healthy Bones and Joints
(1993/09) The relationship between boron and magnesium status and bone mineral density in the human: a review.
(2015/10) The Impact of Vitamin D, Calcium, Protein Supplementation, and Physical Exercise on Bone Metabolism After Bariatric Surgery: The BABS Study.
(2015/02) The Effect of Calcium or Calcium and Vitamin D Supplementation on Bone Mineral Density in Healthy Males: A Systematic Review and Meta-analysis.
(2012/04) Calcium intake and risk of cardiovascular disease: a review of prospective studies and randomized clinical trials.
(2011/02) Calcium supplementation in postmenopausal women to reduce the risk of osteoporotic fractures.
(2010/07) Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis
(2009/12) The effect of calcium supplementation on bone loss in 32 controlled trials in postmenopausal women
(2008/06) Effect of calcium supplementation on fracture risk: a double-blind randomized controlled trial.
(2007/06) Calcium supplementation in clinical practice: a review of forms, doses, and indications.
(2004/04) Comparison of the effects of calcium loading with calcium citrate or calcium carbonate on bone turnover in postmenopausal women.
(2000/11) Pharmacokinetic and pharmacodynamic comparison of two calcium supplements in postmenopausal women.
(1999/11) Meta-analysis of calcium bioavailability: a comparison of calcium citrate with calcium carbonate.
(2015/10) The Impact of Vitamin D, Calcium, Protein Supplementation, and Physical Exercise on Bone Metabolism After Bariatric Surgery: The BABS Study.
(2015/02) The Effect of Calcium or Calcium and Vitamin D Supplementation on Bone Mineral Density in Healthy Males: A Systematic Review and Meta-analysis.
(2011/03) Calcium plus vitamin D supplementation has limited effects on femoral geometric strength in older postmenopausal women: the Women's Health Initiative.
(2010/12) Effect of calcium and vitamin D supplementation on bone mineral density in women aged 65-71 years: a 3-year randomized population-based trial (OSTPRE-FPS)
(2010/09) Reducing fracture risk with calcium and vitamin D.
(2007/08) Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis.
(2006/02) Calcium plus vitamin D supplementation and the risk of fractures.
(2013/01) Accumulation of bone strontium measured by in vivo XRF in rats supplemented with strontium citrate and strontium ranelate.(2008/03) Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia.
(2006/07) Strontium ranelate for preventing and treating postmenopausal osteoporosis.
(2001/09) Mechanisms of action and therapeutic potential of strontium in bone.
(2015/10) The Impact of Vitamin D, Calcium, Protein Supplementation, and Physical Exercise on Bone Metabolism After Bariatric Surgery: The BABS Study.
(2015/03) Serum 25 Hydroxyvitamin D, Bone Mineral Density and Fracture Risk Across the Menopause.
(2015/02) The Effect of Calcium or Calcium and Vitamin D Supplementation on Bone Mineral Density in Healthy Males: A Systematic Review and Meta-analysis.
(2014/12) Dietary Fat Increases Vitamin D-3 Absorption
(2014/09) Does vitamin D affect femoral cartilage thickness? An ultrasonographic study.
(2012/07) A pooled analysis of vitamin D dose requirements for fracture prevention.
(2009/03) Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials
(2008/08) Summary of evidence-based review on vitamin D efficacy and safety in relation to bone health
(2008/08) Serum 25-hydroxyvitamin D and functional outcomes in the elderly.
(2007/08) Effectiveness and safety of vitamin D in relation to bone health.
(2006/09) The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation.
(2012/01) Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials.
(2011/11) Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study.
(2011/06) Dietary vitamin K intake is associated with bone quantitative ultrasound measurements but not with bone peripheral biochemical markers in elderly men and women.
(2011/06) Vitamin K: fracture prevention and beyond.
(2009/06) Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women.
(2008/10) Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.
(2008/05) Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms.
(2008/04) Effect of vitamin K supplementation on bone loss in elderly men and women.
(2007/04) Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women.
(2006/06) Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
(2003/07) Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age.
(2000/05) Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women.
Heart Health
(2019/02) Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.
(2018/09) Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials.
(2012/12) A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndrome.
(2012/11) Impact of coenzyme Q-10 on parameters of cardiorespiratory fitness and muscle performance in older athletes taking statins
(2012/11) The effect of coenzyme Q10 in statin myopathy.
(2012/08) Effect of coenzyme Q10 supplementation on statin-induced myalgias
(2012/02) Strategies to preserve the use of statins in patients with previous muscular adverse effects
(2010/07) Coenzyme Q10: a therapy for hypertension and statin-induced myalgia?
(2009/10) Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension.
(2007/06) The role of coenzyme Q10 in statin-associated myopathy: a systematic review.
(2007/05) Effect of coenzyme q10 on myopathic symptoms in patients treated with statins
(2005/11) Muscle coenzyme Q10 level in statin-related myopathy.
(2004/05) Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study.
(2003/01) Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure.
(1999/05) Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure.
(1999/03) Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease.
(1995/03) Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group.
(1994/12) Coenzyme Q10 in essential hypertension.
(1994/12) Treatment of essential hypertension with coenzyme Q10.
(1994/12) Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators.
(1993/12) Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study.
(2011/11) Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events.
(2011/10) Impact of low vs. moderate intakes of long-chain n-3 fatty acids on risk of coronary heart disease.
(2010/03) Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides
(2010/01) Fish oil for primary and secondary prevention of coronary heart disease.
(2008/07) Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: subanalysis of the JELIS trial.
(2006/12) The triglyceride-lowering effects of a modest dose of docosahexaenoic acid alone versus in combination with low dose eicosapentaenoic acid in patients with coronary artery disease and elevated triglycerides.
(2006/08) Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids.
(2006/08) Secondary prevention of coronary artery disease with omega-3 fatty acids.
(2006/08) Combination Therapy with Statins and Omega-3 Fatty Acids
(2006/08) Dietary omega-3 fatty acid intake and cardiovascular risk.
(2006/03) The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans.
(2002/11) Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
(1999/08) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial.
(2014/11) Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review and meta-analysis
(2012/05) Vitamin D levels predict all-cause and cardiovascular disease mortality in subjects with the metabolic syndrome: the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study.
Immune Function
Joint Health
(2013/03) Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate: what's the evidence?
(2011/11) Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center.
(2011/06) Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI.
(2010/06) Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration.
(2010/06) Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study
(2009/02) Long-Term Effects of Chondroitins 4 and 6 Sulfate on Knee Osteoarthritis
(2008/09) Potential effects of chondroitin sulfate on joint swelling: a GAIT report.
(2007/01) Symptom and Structure Modifying Properties of Chondroitin Sulfate in Osteoarthritis
(2005/03) Chondroitins 4 and 6 Sulfate in Osteoarthritis of the Knee
(2012/06) Crystalline glucosamine sulfate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties.
(2011/11) Statement on the safety of glucosamine for patients receiving coumarin anticoagulants
(2011/07) Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial.
(2011/04) The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature.
(2009/04) Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database
(2011/01) A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals.
(2009/04) Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial.
(2007/03) Current role of glucosamine in the treatment of osteoarthritis. Review
(2006/11) Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis
(2005/01) Glucosamine therapy for treating osteoarthritis
(2003/12) Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate.
(2013/12) Naturocetic (glucosamine and chondroitin sulfate) compounds as structure-modifying drugs in the treatment of osteoarthritis.
(2010/09) Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis.
(2010/03) The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination.
(2010/01) Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis.
(2009/11) The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation.
(2009/01) A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis
(2008/10) The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial.
(2006/02) Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis
(2006/02) Nutritional Supplements for Knee Osteoarthritis - Still No Resolution
(2003/07) Structural and Symptomatic Efficacy of Glucosamine and Chondroitin in Knee Osteoarthritis
Sleep Health
