Fertility Scientific References
Fertility | Women's Health | Urology | Rheumatology | General Health
LATEST RESEARCH UPDATE: A recent systematic review and meta-analysis of eight randomized controlled trials (RCTs) summarized the effects of myoinositol (MI) supplementation on controlled ovarian hyperstimulation (COH) variables (gonadotropin use, duration of stimulation, and number of canceled cycles) in both patients with and without PCOS, undergoing IVF. The analysis of six studies comparing MI to control found a significant reduction in length of COH and gonadotropin dose, without differences in canceled cycle rate, number of total and mature oocytes per cycle, and clinical pregnancy rate per cycle. In summary, inositol reduced the amount of gonadotropins used in both PCOS and non-PCOS women and reduced COH length in women with PCOS. For more information, check out the full abstract here.
Female Fertility
(2018/10) CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity.
(2018/03) Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial.
(2017/05) The association between coenzyme Q10 concentrations in follicular fluid with embryo morphokinetics and pregnancy rate in assisted reproductive techniques.
(2015/10) Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.
(2014/06) Coenzyme Q10 Supplementation and Oocyte Aneuploidy in Women Undergoing IVF-ICSI Treatment.
(2013/01) The aging oocyte--can mitochondrial function be improved?
(2012/04) Coenzyme Q10 content in follicular fluid and its relationship with oocyte fertilization and embryo grading
(2017/05) The effect of dehydroepiandrosterone supplementation on ovarian response is associated with androgen receptor in diminished ovarian reserve women.
(2016/07) Effect of dehydroepiandrosterone administration in Chinese women over 37 years undergoing assisted reproductive techniques.
(2016/05) The effect of dehydroepiandrosterone (DHEA) supplementation on women with diminished ovarian reserve (DOR) in IVF cycle: Evidence from a meta-analysis.
(2015/12) A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection.
(2015/03) Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in women younger than 40 years old.
(2015/02) Potential benefit of dehydroepiandrosterone supplementation for infertile but not poor responder patients in a IVF program.
(2014/07) A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders.
(2014/06) Effect of dehydroepiandrosterone administration in patients with poor ovarian response according to the Bologna criteria.
(2014/06) Role of dehydroepiandrosterone in improving oocyte and embryo quality in IVF cycles.
(2014/02) Does dehydroepiandrosterone supplementation really affect IVF-ICSI outcome in women with poor ovarian reserve?
(2014/01) DHEA pre-treated patients, poor responders to a first IVF (ICSI) cycle: clinical results.
(2013/11) A prospective study on role of dehydroepiandrosterone (DHEA) on improving the ovarian reserve markers in infertile patients with poor ovarian reserve.
(2013/10) DHEA supplementation positively affects spontaneous pregnancies in women with diminished ovarian function.
(2013/07) Dehydroepiandrosterone supplementation improves predictive markers for diminished ovarian reserve: serum AMH, inhibin B and antral follicle count.
(2013/05) DHEA supplementation may improve IVF outcome in poor responders: a proposed mechanism.
(2013/01) Starting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization(IVF) pregnancy rates in women with diminished ovarian reserve (DOR).
(2012/09) DHEA supplementation improves follicular microenviroment in poor responder patients.
(2010/10) Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study.
(2010/11) Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: direct evidence from preimplantation genetic screening (PGS).
(2010/10) Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study.
(2017/12) Periconceptional maternal fever, folic acid intake, and the risk for neural tube defects.
(2016/12) Effects of folic acid supplementation during different pregnancy periods and relationship with the other primary prevention measures to neural tube defects.
(2015/12) Effects and safety of periconceptional oral folate supplementation for preventing birth defects.
(2015/01) Folic acid supplementation and dietary folate intake, and risk of preeclampsia.
(2013/09) Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?
(2019/01) Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial.
(2018/12) Inositol for subfertile women with polycystic ovary syndrome.
(2018/10) Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials.
(2018/02) Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials.
(2017/12) Inositol supplement improves clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET.
(10/2016) Inositol Treatment and ART Outcomes in Women with PCOS.
(08/2016) Prospective Randomized Study on the Influence of Myoinositol in PCOS Women Undergoing IVF in the Improvement of Oocyte Quality, Fertilization Rate, and Embryo Quality
(08/2015) Inositol versus Metformin administration in polycystic ovary syndrome patients: a case–control study
(06/2015) Myo-inositol therapy for poor-responders during IVF: a prospective controlled observational trial
(02/2015) Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance
(12/2013) The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial
(04/2013) Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study.
(07/2012) Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study.
(05/2011) Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double-blind trial.
(04/2011) Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial.
(04/2010) Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women.
(05/2009) Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial.
(09/2007) Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS.
(2017/12) The impact of melatonin on the sleep patterns of women undergoing IVF: a double blind RCT.
(2017/04) Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve.
(2016/01) Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome.
(2014/10) Melatonin: shedding light on infertility? - a review of the recent literature.
(2014/05) Oral melatonin supplementation improves oocyte and embryo quality in women undergoing in vitro fertilization-embryo transfer.
(2014/01) Melatonin supplementation during controlled ovarian stimulation for women undergoing assisted reproductive technology: systematic review and meta-analysis of randomized controlled trials.
(2012/02) The efficacy of melatonin administration on oocyte quality.
(2011/11) Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.
(2011/09) Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.
(2010/06) Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial.
(2008/04) Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.
(2018/01) Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction.
(2017/12) The association between fatty acid index and in vitro fertilization outcomes.
(2017/11) Omega-3 fatty acid supplementation significantly lowers FSH in young normal weight women.
(2012/11) Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids.
(2011/04) Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology.
(2010/09) The effect of supplementation with omega-3-polyunsaturated fatty acids in intracytoplasmic sperm injection cycles for infertile patients with a history of unexplained total fertilization failure.
(2018/05) Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study.
(2018/01) Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis.
(2014/11) Vitamin D deficiency and infertility: insights from in vitro fertilization cycles.
(2014/09) Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI.
(2014/07) Association Between Sex Steroids, Ovarian Reserve, and Vitamin D Levels in Healthy Nonobese Women
(2014/04) Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization
(2014/02) Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles.
(2013/06) Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization.
(2012/11) Characterizing the influence of vitamin D levels on IVF outcomes.
(2011/08) Predictive value of the level of vitamin D in follicular fluid on the outcome of assisted reproductive technology
(2010/09) Replete vitamin D stores predict reproductive success following in vitro fertilization.
(2010/07) Prognostic value of follicular fluid 25-OH vitamin D and glucose levels in the IVF outcome
Male Fertility
(2018/01) Systematic review of antioxidant types and doses in male infertility: Benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate.
(2016/12) Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters.
(2015/09) Oral antioxidant treatment partly improves integrity of human sperm DNA in infertile grade I varicocele patients.
(2013/06) Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA.
(2012/11) Micronutrients intake is associated with improved sperm DNA quality in older men.
(2014/03) Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial.
(2012/08) Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study
(2011/09) Coenzyme Q(10) in male infertility: physiopathology and therapy
(2011/09) Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial.
(2009/07) Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men.
(2009/05) Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial.
(2009/08) Low folate in seminal plasma is associated with increased sperm DNA damage
(2008/05) The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men.
(2002/03) Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial.
(2001/02) Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers.
(2015/09) Oral antioxidant treatment partly improves integrity of human sperm DNA in infertile grade I varicocele patients.
(2015/09) Efficacy of tamoxifen and l-carnitine on sperm ultrastructure and seminal oxidative stress in patients with idiopathic oligoasthenoteratozoospermia.
(2015/06) Protective effects of l-carnitine on astheno- and normozoospermic human semen samples during cryopreservation.
(2015/01) Effect and safety of L-carnitine in the treatment of idiopathic oligoasthenozoospermia: a systemic review.
(2010/06) Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study.
(2007/12) Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review.
(2006/05) Carnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trial.
(2005/12) The effects of L-carnitine on sperm parameters in smoker and non-smoker patients with idiopathic sperm abnormalities.
(2005/09) Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia.
(2003/02) Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial.
(2016/12) Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation.
(2016/04) Association of decreased spermatozoa omega-3 fatty acid levels and increased oxidative DNA damage with varicocele in infertile men: a case control study.
(2015/05) Dietary fatty acids affect semen quality: a review.
(2012/05) Dietary fat and semen quality among men attending a fertility clinic.
(2010/02) Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men.
(2011/01) Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate
(2009/02) Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study
(2003/03) Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men.
(1998/07) The effect of oral selenium supplementation on human sperm motility.
(2015/11) Males with low serum levels of vitamin D have lower pregnancy rates when ovulation induction and timed intercourse are used as a treatment for infertile couples: results from a pilot study.
(2012/05) Vitamin D and fertility: a systematic review.
(2011/06) Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa.
(2011/01) Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate
(2010/05) Combination clomiphene citrate and antioxidant therapy for idiopathic male infertility: a randomized controlled trial
(2003/03) Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men.
(1996/09) Lipid peroxidation and human sperm motility: protective role of vitamin E.
(1996/09) The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program.
(1995/10) A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility.
(2008/05) The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men.
(2002/03) Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial
(2000/01) Comparison of zinc concentrations in blood and seminal plasma and the various sperm parameters between fertile and infertile men.
(1999/03) Relationship between zinc concentrations in seminal plasma and various sperm parameters.
(1998/01) Changes in seminal quality following oral zinc therapy.
